Rochester - Karen (Sylvain) Regis, 70, passed away Friday June 28, 2024 in her home. Karen was born June 19, 1954 to Ernest and Claire (Henry) Sylvain in Austin, TX. She graduated from Portsmouth High School in Portsmouth, NH in 1972. Karen was politically active her whole life, including protesting nuclear power with the Seacoast Anti-pollution League in the 70's. She took time to write to her congressmen and senators throughout the years showing she was a true patriot. She loved writing letters and sending beautiful cards to her loved ones. Karen also enjoyed baking, often bringing her baked goods to church for refreshments. Karen was extremely proud of all her children, and particularly proud that she had 3 of the births at home. She was a beautiful human inside and out. She was thoughtful and sentimental. She adored her grandchildren. Karen was a tenacious individual and never let life's curveballs stop her. She is survived by her four children, Luke (Denise) Harris of Moorseville, NC; Timothy (Lynn Limauro) Bush of Spring Lake, MI; Joanna Bush of Berwick, ME; and Bethany Bush of Rochester, NH; She is also survived by her eleven grandchildren Caden, Seth, Joel, Troy, Rachel, Molly Beth Harris, Dylan Limauro, Jaden Briggs, Mason Kingston, and Thea Mathews, as well as her two sisters Susan Sanders of Mesa, AZ; and Nancy Roy of Rochester, NH. She is preceded in death by her husband Clovis Regis (10/7/2013), her parents Ernest Sylvain (12/12/2020) and Claire (Henry) Sylvain (9/3/2011) and her brothers Norman Sylvain (2013) and Dennis Sylvain (10/25/2008). Karen loved her lord and savoir Jesus Christ, her church, her family, and nature. She will be missed immensely by all who knew and loved her. In lieu of flowers please consider making a donation in her name to the Kidney Transplant Assistance Fund, at Maine Medical Center in Portland, ME. Services will be held at True Memorial Baptist Church, 21 Ten Rod Rd., Rochester NH on July 27 at 10:00am.